Carbetocin

Therapeutic

Used to control postpartum hemorrhage and bleeding after giving birth.

Structural features

SMILES

[H][C@]1(NC(=O)[C@H](CC2=CC=C(OC)C=C2)NC(=O)CCCSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)[C@@H](C)CC

Sequence

XXIQNCPLG-NH2

Molar mass

988.17 g/mol

Constitutional members:

9

Natural amino acids

7

D-Amino acids

0

N-terminus

butyril

C-terminus

NH2

Cyclic

yes

Members/cycle

6

Bond to form cycle

thioether

Lipidation

no

Glycosylation

no

Route of administration

IV, IM

Terminal half-life

40 min

Protein binding

Absorption and Bioavailability

80% (IM)

References